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- <text id=89TT1511>
- <title>
- June 12, 1989: Gene-Splicing Revolution?
- </title>
- <history>
- TIME--The Weekly Newsmagazine--1989
- June 12, 1989 Massacre In Beijing
- </history>
- <article>
- <source>Time Magazine</source>
- <hdr>
- SCIENCE, Page 59
- Gene-Splicing Revolution?
- </hdr><body>
- <p>A new bioengineering method lets sperm do the work
- </p>
- <p> The claim is so dramatic and startling that some
- biologists, perhaps mindful of the recent flap over test-tube
- atomic fusion, have been wary of taking it at face value. But
- an experiment reported by researchers at the University of Rome
- and at that city's Institute of Biomedical Technology may mean
- that the genetic engineering of animals -- grafting
- characteristics from one organism onto another -- has taken a
- major step forward.
- </p>
- <p> Instead of using the conventional technique of
- painstakingly inserting foreign genes into an egg cell with a
- tiny needle, the scientists simply bathed sperm cells in a
- solution of bacterial DNA. The sperm, from mice, incorporated
- the genes by some still unknown process, then went on to
- fertilize eggs in a test tube. As the mice matured, 30% of them
- produced an enzyme normally made only by bacteria -- proof that
- the bacterial DNA had become part of the mice's genetic makeup.
- </p>
- <p> The experiment has been called a potential "cornerstone in
- biology." Maybe so, but it will hardly make genetic engineering
- a kitchen-table technology. Advocates of gene transplants have
- long pointed to the potential benefits of altered animals --
- disease-resistant pigs, fast-growing cows and the like. Medical
- researchers are already using engineered mice to study the
- mechanics of cancer and heart disease. But genetic engineering
- is a process that involves many difficult steps, and the new
- breakthrough will at best simplify just one of them.
- </p>
- <p> Those limitations should help allay the worst fear of
- biotech watchers: the new technique could be used by unethical
- researchers to manipulate the genetic makeup of humans. "It's
- amazing if true, and would make our work much easier," says
- Steven Holtzman of Embryogen Corp., a biotechnology firm with
- labs in Princeton, N.J. But no one is about to abandon the
- standard technique until other scientists complete tests of the
- Italians' work -- a process that is already well under way.
- </p>
-
- </body></article>
- </text>
-
-